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This MC1R selectivity makes it a more targeted research tool for melanocyte biology studies, though it retains measurable activity at other melanocortin receptor subtypes in binding assays

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Double-blind placebo-controlled study with PT-141 (MC4R-selective derivative of Melanotan II) 20 mg intranasally

In particular, nitric oxide (NO) regulates vascular tone and blood flow by promoting the relaxation of all types of blood vessels, including arteries a phenomenon called vasodilation